The present application provides a composition for efficiently inducing apoptosis in a cell and/or inhibiting proliferation, and a method of using the composition.The present application is directed to a preparation for inducing apoptosis, the preparation comprising a medicament for inhibiting GST-π and a medicament for inhibiting Akt as active ingredients. The present application is further directed to a pharmaceutical composition comprising the preparation, and a method of treating a disorder associated with abnormal apoptosis by using the preparation.本發明之目的在於提供一種用以在細胞中有效地誘導細胞凋亡及/或增殖抑制之組成物、及使用該組成物之方法。本發明是關於:一種製劑,用以誘導細胞凋亡,該製劑含有抑制GST-π之藥物和抑制Akt之藥物來作為活性成分;一種含有該製劑之醫藥組成物;及,一種使用該製劑之因細胞凋亡的異常而伴隨發生的疾病之處置方法