ИНГИБИТОР PI3K, ПРЕДНАЗНАЧЕННЫЙ ДЛЯ ПРИМЕНЕНИЯ ДЛЯ ЛЕЧЕНИЯ РАКА КОСТИ ИЛИ ДЛЯ ПРЕДУПРЕЖДЕНИЯ МЕТАСТАТИЧЕСКОЙ ДИССЕМИНАЦИИ ПЕРВИЧНЫХ РАКОВЫХ КЛЕТОК В КОСТЬ
ДЕ ДЖОВАННИ Карла (IT),ЛОЛЛИНИ Пьер-Луиджи (IT),НАННИ Патриция (IT)
申请号：
RU2014112320/15
公开号：
RU2014112320A
申请日:
2012.08.31
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating a subject or preventing bone cancer, in need of such treatment comprising administering to the subject a compound of formula (I): wherein W is CH Roznachaet N-morpholinyl is hydrogen Roznachaet trifluoromethyl is hydrogen, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof for treating cancer kosti.2. The method of claim. 1, wherein the bone cancer is selected from the group consisting of chondrosarcoma, osteosarcoma, Ewings sarcoma, chordoma, fibrosarcoma and malignant fibrous histiocytoma (MFH) .3. A method for preventing metastatic dissemination of cancer cells in primary bone subject in need of such prevention, comprising administering to the subject a compound of formula (I) according to Claim. 1 or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof for the prevention of metastatic dissemination of cancer cells in primary bone subekta.4 . The method of claim. 3, wherein the primary cancer cells derived from breast, lung, pancreas, prostate or kidney zhelezy.5. The method of claim. 3 or 4, wherein the primary cancer cells are breast cancer cells zhelezy.6. A compound of formula (I) wherein W is CH Roznachaet N-morpholinyl is hydrogen Roznachaet trifluoromethyl is hydrogen, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, for the treatment or prevention of cancer kosti.7. A compound of formula (I) according to claim. 6, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein the bone cancer is selected from the group consisting of chondrosarcoma, osteosarcoma, Ewings sarcoma, chordoma, fibrosarcoma and malignant fibrous histiocytoma (MFH) .8. The compound of formula1. Способ лечения или предупреждения рака кости у субъекта, нуждающегося в таком лечении, включающий введение субъекту соединения формулы (I):где W означает CHR1 означает N-морфолинилR2 означает водородR3 означает трифторметилR4 означает водород,или его стереоизомера, таутомера, или фарм
