A medicament comprising the following composition: (A) an angiotensin IIreceptorantagonist selected from the group of a compound having a general formula (I),pharmacologically acceptable esters thereof and pharmacologically acceptablesaltsthereof (for example, olmesartan medoxomil and the like);(see formula I)and (B) a calcium channel blocker selected from the group consisting of1,4-dihydropyridine derivatives and pharmacologically acceptable salts thereofas activeingredients (for example, azelnidipine and the like) for the prophylaxisand/or treatmentof arteriosclerosis, hypertension, heart diseases, renal diseases orcerebrovasculardiseases.