Bryon E. Petersen,Seh-Hoon Oh,Thomas Shupe,Houda Darwiche
申请号：
US14116368
公开号：
US09109042B2
申请日:
2012.05.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Type-1 diabetes (T1 D) results from the autoimmune recognition of insulin producing β-cells within the pancreatic islet. The present application discloses a new protein, islet homeostasis protein (IHoP), that has a role in glucagon synthesizing-cell functions, and in post-onset T1 D islet differential expression of IHoP. Methods of delaying the onset of diabetes are disclosed, as well as compositions including an iHoP modulating agent. Also disclosed are methods of screening for iHoP modulating agents.
