What is disclosed is a system and method for determining arterial pulse wave transit time for a subject. In one embodiment, a video is received comprising a plurality of time-sequential image frames of a region of exposed skin of a subject where a videoplethysmographic (VPG) signal can be registered by at least one imaging channel of the video device used to capture that video. Also received is an electrocardiogram (ECG) signal obtained using at least one sensor placed on the subject's body where a ECG signal can be obtained. Batches of image frames are processed to obtain a continuous VPG signal for the subject. Temporally overlapping VPG and ECG signals are analyzed to obtain a pulse wave transit time between a reference point on the VPG signal and a reference point on the ECG signal. The pulse transit time is used to assess pathologic conditions such as peripheral vascular disease.
