您的位置: 首页 > 农业专利 > 详情页

取代二氫吡唑啉酮和它們作爲HIF-脯氨酰-4-羥化酶抑制劑的用途
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
THEDE, KAI,FLAMME, INGO,OEHME, FELIX,ERGDEN, JENS-KERIM,STOLL, FRIEDERIKE,SCHUHMACHER, JOACHIM,WILD, HANNO,KOLKHOF, PETER,BECK, HARTMUT,AKBABA, METIN,JESKE, MARIO
申请号:
HK10102676.5
公开号:
HK1137756B
申请日:
2010.03.15
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
Substituted dihydropyrazolone derivatives (I) are new. Substituted dihydropyrazolone derivatives of formula (I) are new. R 1>;heteroaryl compounds of formula (a) or (b); A : C-R 4>; or N, where maximum two ring members of A are simultaneously N; E : C-R 5>; or N, where maximum two ring members of E are simultaneously N; R 2>;nitrogen containing heteroaryl-group of formula (c)-(o); a1, a2 : point of attachment with the dihydropyrazolthione ring; G : C-R 6>; or N, where maximum two ring members of G are simultaneously N; J : O, S or N-R 7>;; L : C-R 8>; or N, where maximum two ring members of L are simultaneously N; M : C-R 9>; or N, where maximum two ring members of M are simultaneously N; R 4>;, R 6>;, R 8>;, R 9>;H, halo, cyano, NO 2, (1-6C)-alkyl (substituted with 1-3 of T), (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl (where the (hetero)cycloalkyl, phenyl and heteroaryl are substituted with 1-3 of T 1>;), -C(=O)-R 1>; 0>;, -C(=O)-OR 1>; 1>;, -C(=O)-NR 1>; 2>;R 1>; 3>;, -O-C(=O)-R 1>; 4>;, -O-C(=O)-NR 1>; 5>;R 1>; 6>;, -NR 1>; 7>;-C(=O)-R 1>; 8>;, -NR 1>; 9>;-C(=O)-OR 2>; 0>;, -NR 2>; 1>;-C(=O)-NR 2>; 2>;R 2>; 3>;, -NR 2>; 4>;-SO 2-R 2>; 5>;, -SO 2-R 2>; 6>;, -SO 2-NR 2>; 7>;R 2>; 8>;, -OR 2>; 9>;, -SR 3>; 0>; or -NR 3>; 1>;R 3>; 2>;; T : halo, CN, oxo, (3-7C)-cycloalkyl, 4-7-membered heterocycloalkyl, phenyl, 5- or 6-membered heteroaryl, -C(=O)-R 1>;0, -C(=O)-OR 1>; 1>;, -C(=O)-NR 1>; 2>;R 1>; 3>;, -O-C(=O)-R 1>; 4>;, -O-C(=O)-NR 1>; 5>;R 1>; 6>;, -NR 1>; 7>;-C(=O)-R 1>; 8>;, -NR 1>; 9>;-C(=O)-OR 2>; 0>;, -NR 2>; 1>;-C(=O)-NR 2>; 2>;R 2>; 3>;, -NR 2>; 4>;-SO 2-R 2>; 5>;, -SO 2-R 2>; 6>;, -SO 2-NR 2>; 7>;R 2>; 8>;, -OR 2>; 9>;, -SR 3>; 0>; or -NR 3>; 1>;R 3>; 2>;, where the cycloalkyl-, heterocycloalkyl-, phenyl- and he
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充