PROBLEM TO BE SOLVED: To provide a new semi-synthetic macrolide compound which has an immunomodulation activity and minimizes side effects.SOLUTION: This new semi-synthetic macrolide compound is obtained by converting a specific site of rapamycin into a specific substituent. The semi-synthetic macrolide has an immunomodulation action, and is effective for autoimmune diseases such as rejection, chronic articular rheumatism, systemic lupus erythematosus, chronic lymphocytic thyroiditis (Hashimoto disease), multiple sclerosis, myasthenia gravis, type I diabetes, uveitis, allergic encephalomyelitis, and glomerulonephritis.COPYRIGHT: (C)2008,JPO&INPIT【課題】免疫調節活性を有し、かつ、副作用を最小限にした新規半合成マクロライドを提供する。【解決手段】ラパマイシンの特定の部位を特定の置換基に変換して、新規半合成マクロライドを得る。免疫調節作用を有し、臓器の移植による拒絶反応、慢性間接リューマチ、全身エリテマトーデス、慢性リンパ球性甲状腺炎(橋本病)、多発性硬化症、重症筋無力症、I型糖尿病、ブドウ膜炎、アレルギー性脳脊髄炎、糸球体腎炎等の自己免疫疾患に有効である。【選択図】なし
