A cable threader device for passing a guide cable between pedicle screws during minimally invasive spinal surgery, the device comprising a handle with a trigger mechanism, the handle mounted onto an elongated shaft having a curved free end with a detachable curved lead member retained in telescoping manner on the end of the body. The guide cable is affixed to the lead member, the instrument is inserted into a first screw tower, the trigger mechanism is activated to advance the lead member into the adjacent tower, and the lead member and guide cable are retrieved through the second tower.