INSERM (Institut National de la Santé et de la Recherche Médicale);Universite Paris - SUD;Université de Rennes;Université Paris Descartes
发明人:
Anne DUBART KUPPERSCHMITT,Anne WEBER BENAROUS,Anne CORLU,Noushin DIANAT
申请号：
US15125596
公开号：
US20160376557A1
申请日:
2015.03.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
