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Substituted N-(pyrazol-5-yl)-pyrrolo[3,2-D]pyrimidin-4-amine useful as protein kinase inhibitors
专利权人:
David Bebbington
发明人:
David Bebbington,Hayley Binch,Ronald Knegtel,Julian M.C. Golec,Sanjay Patel,Jean-Damien Charrier,David Kay,Robert Davies,Pan Li,Marion Wannamaker,Cornelia Forster,Albert Pierce
申请号:
US12651639
公开号:
US08524720B2
申请日:
2010.01.04
申请国别(地区):
US
年份:
2013
代理人:
摘要:
This invention describes novel pyrazole compounds of formula IV:wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimers disease.
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