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6-OXO-1,6-DIHYDRO-PYRIDISINE DERIVATIVE FOR USE IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA (FCC)
专利权人:
МЕРК ПАТЕНТ ГМБХ (DE)
发明人:
ФРИЗЕ-ХАМИМ Маня (DE),БЛАДТ Фридхельм (DE)
申请号:
RU2015120692
公开号:
RU2015120692A
申请日:
2013.10.04
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. 3- (1- {3- [5- (1-Methyl-piperidin-4-ylmethoxy) -pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl ) -benzonitrile or a pharmaceutically acceptable salt and / or solvate thereof for use in the treatment of hepatocellular carcinoma (HCC) .2. 3- (1- {3- [5- (1-methyl-piperidin-4-ylmethoxy) pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl hydrochloride hydrate ) -benzonitrile for use in the treatment of hepatocellular carcinoma (HCC) .3. 3- (1- {3- [5- (1-Methyl-piperidin-4-ylmethoxy) -pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl) - benzonitrile according to claim 1 or 2, wherein the compound is administered to the patient in an amount of from 100 mg to 800 mg per day. 3- (1- {3- [5- (1-Methyl-piperidin-4-ylmethoxy) -pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl) - benzonitrile according to claim 1 or 2, wherein the compound is administered orally. Use of 3- (1- {3- [5- (1-methyl-piperidin-4-ylmethoxy) -pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl) -benzonitrile or a pharmaceutically acceptable salt and / or solvate thereof for the manufacture of a medicament for the treatment of hepatocellular carcinoma (HCC) .6. Use of 3- (1- {3- [5- (1-methyl-piperidin-4-ylmethoxy) pyrimidin-2-yl] benzyl} -6-oxo-1,6-dihydro-pyridazin-3- hydrochloride hydrate il) -benzonitrile for the manufacture of a medicament for the treatment of hepatocellular carcinoma (HCC) .7. The use according to claim 5 or 6, wherein the compound is administered to the patient in an amount of from 100 mg to 800 mg per day. The use of claim 5 or 6, wherein the compound is administered orally.1. 3-(1-{3-[5-(1-Метил-пиперидин-4-илметокси)-пиримидин-2-ил]-бензил}-6-оксо-1,6-дигидро-пиридазин-3-ил)-бензонитрил или его фармацевтически приемлемая соль и/или сольват для применения в лечении гепатоцеллюлярной карциномы (ГЦК).2. Гидрат гидрохлорида 3-(1-{3-[5-(1-метил-пиперидин-4-илметокси)-пиримидин-2-ил]-бензил}-6-оксо-1,6-дигидро-пиридазин-3-ил)-бензонитрила
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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