РОНГВЕД Пол (NO),ОСТРАНД Ове Александер Хёгмоэн (NO),БАЙЕР Аннетт (NO),ЛЕЙРОС Ханна-Кирсти Шрёдер (NO),САМУЭЛЬСЕН Эрьян (NO),ЭДВАРДСЕН Кине Сусанн Воде (NO),МУХАММАД Зеесхан (NO)
申请号：
RU2016116956
公开号：
RU2016116956A
申请日:
2014.10.06
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
Compounds according to formula I are provided: A-L-B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ions L is a covalent bond or a linker and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.
