The invention provides a unit operation formed by a device and its use for continuous virus inactivation of a continuous flow of a process fluid. The unit operation formed by a device comprises a single inlet at one end and an outlet at the opposite end and at least one HFI, characterized in that the HFI further comprises at least one installation.本發明提供一種藉由裝置所形成的單元操作及其用於製程流體之連續流動的連續病毒滅活之應用。藉由裝置所形成的單元操作包含在一端部之單個入口和在該相反端部的出口以及至少一個HFI,其特徵在於該HFI另包含至少一個設備。