The present invention relates to compositions comprising: a) a Vitis vinifera extract in free form or in the form of a complex with phospholipids, or a Punica granatum extract； and b) a lipophilic extract of Zingiber officinale； and c) a lipophilic extract obtained from plants containing polyunsaturated fatty acid isobutylamides selected from the group consisting of Echinacea spp. extract or Zanthoxylum spp. extract or Acmella oleracea (or Spilanthes oleracea) extract； and d) an unsaponifiable fraction of olive oil and/or corn oil； or e) N-acetyl glucosamine； or f) diacerein； and their use in the prevention and/or treatment of osteoarticular inflammation and pain, and cartilage damage.
