FERNANDEZ, MARIA CARMEN,GONZALEZ-GARCIA, MARIA ROSARIO,PFEIFER, LANCE ALLEN
申请号：
PE0011972014
公开号：
PE16792014A1
申请日:
2013.01.24
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to Derivatives of benzyl sulfonamide compounds of formula (i) wherein R1 is - CH3 or - Cf3 R2 is H, CH3, ch2och3 - or - ch2och2ch3 R3 is H, alkyl (C1, C2) - or - ch2och3 ch2och2ch3 R4 is H, Halo or - OCH3 R5 is H or Halo is CH, C - F, - CN c or N X is CH, C - C o n f, - OCH3.Preferred compounds are: hydrochloride, N - [(1S) - 2,2,2-trifluoro-1 - ({{4 - [(2S) - 2 - (5 - [fluoropiridin IL - 2 - (3-methoxypropyl) oxy] methyl] phenyl] amino) ethyl] metansulfonamida} {(N -, hydrochloride 1R) - 1 - [4 - ({[(2R) - 2 - (2 - pyridin - iloxi) propyl] amino] methyl) phenyl] ethyl} metansulfonamida among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of the mogat receptor - 2 (monoacilglicerol acyltransferase 2) being useful in the treatment of hypertriglyceridemiaSE REFIERE A COMPUESTOS DERIVADOS DE BENCIL SULFONAMIDA DE FORMULA (I) DONDE R1 ES -CH3 O -CF3 R2 ES H, -CH3, -CH2OCH3 O -CH2OCH2CH3 R3 ES H, ALQUILO(C1-C2), -CH2OCH3 O -CH2OCH2CH3 R4 ES H, HALO O -OCH3 R5 ES H O HALO A ES CH, C-F, C-CN O N X ES CH, C-F, C-OCH3 O N. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE N-[(1S)-2,2,2-TRIFLUORO-1-{4-[({(2S)-2-[(5-FLUOROPIRIDIN-2-IL)OXI]-3-METOXIPROPIL}AMINO)METIL]FENIL}ETIL]METANSULFONAMIDA CLORHIDRATO DE N-{(1R)-1-[4-({[(2R)-2-(PIRIDIN-2-ILOXI)PROPIL]AMINO}METIL)FENIL]ETIL}METANSULFONAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR MOGAT-2 (MONOACILGLICEROL ACILTRANSFERASA-2) SIENDO UTILES EN EL TRATAMIENTO DE HIPERTRIGLICERIDEMIA
