Apparatuses, systems, and methods involve using reduced pressure to position a portion of tissue in a cutting head and cutting the tissue to debride a tissue site. A cutting head includes a debridement conduit having a distal end and a proximal end. A portion of the debridement conduit adjacent to the distal end comprises a tissue treatment area. The cutting head also includes an opening to the tissue treatment area formed at the distal end of the debridement conduit. The tissue treatment area is adapted to receive the portion of tissue through the opening under reduced pressure. The cutting head also includes a selectively moveable cutting member associated with the debridement conduit at the tissue treatment area. The cutting member is for cutting the portion of tissue from the tissue site while the portion of tissue resides in the debridement conduit. Other methods, systems, and apparatuses are disclosed.