LI, JI,SHEN, WENYAN,LU, HSIENG SEN,RICHARDS, WILLIAM GLEASON
申请号：
CA2574881
公开号：
CA2574881C
申请日:
2005.08.04
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides antibodies and immunologically functionalfragments thereof that specifically bind Dkk-1 polypeptides. The subjectantibodies and fragments bind with high affinity to a conformational epitopelocated in the carboxy region of the Dkk-1 protein. Methods for preparing suchantibodies or fragments thereof as well as physiologically acceptablecompositions containing the antibodies or fragments are also provided. Use ofthe antibodies and fragments to treat various diseases including bonedisorders, inflammatory diseases, neurological diseases, ocular diseases,renal diseases, pulmonary diseases and skin diseases are also disclosed.
