Disclosed are means, methods, and compositions of matter useful for treatment of cancer through integrated immunotherapy. In one embodiment a synergistic protocol is comprised of: a) establishing a proteomic, genomic, and immunological profile of the patient； b) stimulation of a change in the tumor microenvironment in order to modify the tumor microenvironment to be more conducive to immunotherapy； c) priming the immune system in order to be prepared for immune activation； d) activate vaccination in order to induce antigen specific immune responses； e) induction of damage to the tumor in an immunogenic manner； f) immune focusing by utilization of epitope specific vaccination； and g) boosting the immune response.
