Steven J. Norris,Jing-Ren Zhang,John M. Hardham,Jerrilyn K. Howell,Alan G. Barbour,George M. Weinstock
申请号：
US13738518
公开号：
US09212218B2
申请日:
2013.01.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
