A guidewire positioning device and method for guiding and positioning a guidewire into a branch vessel of a main body vessel are disclosed. The device comprises a guidewire positioning tube attached to a torquable wire shaft. The distal end of the positioning tube is curved at an angle to the axis of the wire shaft. To position a guidewire into a branch body vessel, the guidewire is inserted into a main body vessel and the guidewire positioning device is advanced over the guidewire to the location of the bifurcation. The distal end of the positioning tube is positioned to point toward the targeted branch vessel by advancing or torquing the positioning device. The guidewire is advanced through the guidewire positioning tube and the curved distal end of the guidewire tube is used to direct the guidewire to enter the targeted branch vessel.