Donald Rao,Zhaohui Wang,John J. Nemunaitis,Changyi Chen,Qizhi Yao
申请号：
US13738742
公开号：
US20130295160A1
申请日:
2013.01.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A miR-196a antagonist capable of inhibiting a miR-196a activity, the miR-196a antagonist comprising one or more target sites for miR-196a. Included is also an expression vector comprising a promoter and a nucleic acid insert operably linked to the promoter, wherein the insert encodes one or more miR-196a antagonists capable of inhibiting a miR-196a activity. In one example, the one or more miR-196a antagonists comprise at least one stem-loop structure comprising a guide strand that comprises a sequence that is complementary to miR-196a, the stem-loop structure further comprising a passenger strand that comprises a mismatch.
