THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NOVARTIS AG
发明人:
ENGELS, BORIS,IDAMAKANTI, NEERAJA,JUNE, CARL H.,LOEW, ANDREAS,MILONE, MICHAEL C.,SONG, HUIJUAN,WANG, ENXIU,WU, QILONG,BEATTY, GREGORY
申请号：
CA2961636
公开号：
CA2961636A1
申请日:
2015.09.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a "NKR-CAR" which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
