Apparatus and methods for promoting hemostasis are provided. The apparatuses and methods have particular applicability with tissue puncture closure devices for sealing percutaneous punctures in arteries. In one embodiment, an apparatus for promoting hemostasis a tube having at least one indentation for holding a hemostatic substance. In further embodiments, the apparatus may further include a carrier tube for forming a lid for the indentation, a retractable sheath for forming a lid for the indentation, or a cover for forming a lid of the indentation. In an alternative embodiment the apparatus for promoting hemostasis comprises a suture provided with a hemostatic substance.
