Method of inhibiting HIV-1 replication by administering modified GP41 C34 peptide derivatives with enhanced pharmacological properties

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专利权人:

Dong Xie

发明人:

Dong Xie,He Jiang

申请号：

US12567250

公开号：

US08470527B2

申请日:

2009.09.25

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1.

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