Relates to a novel use of Polygonati Rhizoma extract or Makoto Polygonati Rhizoma for the prevention and treatment of metabolic syndrome or obesity, obesity, including the Polygonati Rhizoma extract or Makoto Polygonati Rhizoma, the present invention is the prevention of metabolic syndrome or obesity complications and more obesity and using said extract and to a novel use of Polygonati Rhizoma extract or Makoto Polygonati Rhizoma for the manufacture of a therapeutic preparation and the prevention of metabolic syndrome food composition or therapeutic pharmaceutical, obesity, obesity or complications, obesity merger The present invention relates to a method of treating metabolic syndrome or disease. Inhibits adipocyte differentiation, obesity reduces body weight, glucose tolerance and degree of abdominal fat while maintaining a high level the SIRT1, Polygonati Rhizoma extract used useful in the prevention and treatment of metabolic syndrome or obesity or complications Makoto Polygonati Rhizoma can be.本発明は肥満又は代謝症候群の予防及び治療のための眞黄精又は黄精抽出物の新規な用途に関するものであり、より詳しくは眞黄精又は黄精抽出物を含む肥満、肥満合併症又は代謝症候群の予防及び治療用薬学的又は食品組成物、肥満、肥満合併症又は代謝症候群の予防及び治療用製剤を製造するための眞黄精又は黄精抽出物の新規な用途及び前記抽出物を利用した肥満、肥満合併症又は代謝症候群の治療方法に関するものである。眞黄精又は黄精抽出物は脂肪細胞分化を抑制し、SIRT1を高い水準に維持して体重、腹部脂肪及び糖耐性度を減少させて肥満、肥満合併症又は代謝症候群の予防及び治療に有用に使用することができる。