UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
Jianhua LUO,Zhanghui CHEN,Yanping YU,George MICHALOPOULOS,Joel B. NELSON
申请号：
US16427185
公开号：
US20200032346A1
申请日:
2019.05.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.
