ОЛЛЕРЕНШО Джереми (US),РЕЙХАРТ Эмили (US),РОСС Расселл Ф. (US)
申请号：
RU2014119897/14
公开号：
RU2014119897A
申请日:
2012.10.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An implantable device for delivering a bioactive agent to a subject, comprising: a plurality of nanostructures made on the surface of an implantable delivery device and arranged according to a predetermined pattern； a biologically active agent located inside or on the surface of the implantable delivery device. An implantable delivery device according to claim 1, characterized in that the biologically active agent is a component of the composition, the composition further comprising one or more pharmaceutically acceptable excipients and / or a delayed release matrix. An implantable delivery device according to claim 1 or 2, characterized in that the pattern also contains microstructures, wherein the transverse size of the nanostructures is smaller than that of the microstructures. 4. An implantable delivery device according to claim 3, characterized in that the microstructures have a transverse size of more than about 500 nm, and the nanostructures have a transverse size of less than about 300 nm. The implantable delivery device according to claim 3, further comprising secondary nanostructures having a cross-sectional size smaller than the cross-sectional size of the microstructures and larger than the cross-sectional size of the primary nanostructures. 6. The implantable delivery device according to claim 1, wherein at least a portion of the nanostructures have one or more of the following characteristics: a) the distance between the centers is from about 50 nm to about 1 μm, b) their height is from about 10 nm to about 20 microns, c) their aspect ratio is from about 0.15 to about 30.7. Implantable device for1. Имплантируемое устройство для доставки биоактивного агента субъекту включающее:- множество наноструктур, изготовленных на поверхности имплантируемого устройства для доставки и расположенных согласно заданному паттерну；биологически активный агент, находящийся внутри или на поверхности данного имплантируемого устройства для доставки.2. Имплантируемое устрой
