Fritz-Frieder FRICKEL,Matthew Colin Thor FYFE,Premji MEGHANI,Stephen Malcolm THOM
申请号：
US14443351
公开号：
US20150329523A1
申请日:
2013.11.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
In compounds of formula I:R1 to R5, Ar and X1 to X3 have defined meanings. The compounds have anti-inflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes Syk kinase and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
