The present invention relates to a tenofovir monobenzyl ester phosphamide prodrug, preparation method and pharmaceutical use thereof. Specifically, the present invention relates to a compound of general formula (X), or isomer, pharmaceutically-acceptable salt, hydrate or solvate thereof, preparation method and use thereof in the preparation of drugs for treating viral infectious diseases, preferably AIDS infection, hepatitis B or diseases caused by hepatitis B virus.本發明涉及一種替諾福韋單苄酯磷醯胺前驅藥物、其製備方法及其在醫藥上的應用，具體而言，本發明涉及一種如通式（X）所示的化合物或其異構物、可藥用鹽、水合物或溶劑合物，它們的製備方法，以及它們在製備病毒感染性疾病，較佳為在製備愛滋病感染、B型肝炎或B肝病毒引起的疾病的藥物中的應用。
