RUSZYMAH BINTI IDRUS,HAMOUD AL-FAQEH,AMINUDDIN BIN SAIM
申请号：
MYPI 2012700399
公开号：
MY165438A
申请日:
2012.06.20
申请国别(地区):
MY
年份:
2018
代理人:
摘要：
THE PRESENT INVENTION RELATES TO AUTOLOGOUS CHONDROGENIC INDUCED BONE MARROW MESENCHYMAL STEM CELLS FOR USE IN SURGERY-FREE REPAIR OF ARTICULAR CARTILAGE DEFECTS, COMPRISING CHONDROGENIC INDUCED AND CULTURE-EXPANDED BONE MARROW MESENCHYMAL STEM CELLS EXTRACTED FROM A PATIENT WHICH IS RESUSPENDED IN A BASAL MEDIUM TO BE INJECTED INTO THE JOINT OF THE PATIENT. AUTOLOGOUS CHONDROGENIC INDUCED BONE MARROW MESENCHYMAL STEM CELLS TO BE INJECTED INTO THE OSTEOARTHRITIS JOINT OF THE PATIENT FOR USE IN SURGERY-FREE REPAIR OF ARTICULAR CARTILAGE DEFECTS, COMPRISING CHONDROGENIC INDUCED BY A MIXED COMPOSITION OF CHONDROGENIC INDUCTION FACTORS CONTAINING TRANSFORMING GROWTH FACTOR BETA 3, INSULIN LIKE GROWTH FACTOR 1, INSULIN-TRANSFERRIN-SELENIUM (ITS), ASCORBIC ACID-2 PHOSPATE, L-PRALINE, DEXAMETHASONE AND CULTURE-EXPANDED BONE MARROW MESENCHYMAL STEM CELLS EXTRACTED FROM A PATIENT WHICH ARE RESUSPENDED IN A BASAL MEDIUM IN A CULTURE MEDIUM WHEREIN THE CULTURE MEDIUM COMPRISING OF HAM’S F12, HIGH GLUCOSE DULBECCO’S MODIFIED EAGLE MEDIUM, FETAL BOVINE SERUM, ANTIBIOTIC-ANTIMYCOTIC, GLUMAX-1, ASCORBIC ACID AND 4-(-2-HYDROXYETHYL)-1 PIPERAZINETHANESULFONIC ACID (HEPES) BUFFER. (NO DRAWINGS DISCLOSED.)
