PHARMACEUTICAL COMPOSITION COMPRISING (Z)-N-(3-(2,4-DIFLUOROPHENYLAMINO)-1-(4-NITROPHENYL)-3-OXOPROP-1-EN-2-YL)-2-METHOXYBENZAMIDE FOR PREVENTING AND TREATING OF NEURODEGENERATIVE DISEASE
PARK, SANG ICK,박상익,KIM, HYUN YOUNG,김현영,LEE, SUK KYUNG,이숙경
申请号：
KR1020120071703
公开号：
KR1012293650000B1
申请日:
2012.07.02
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition containing (Z)-N-(3-(2,4-difluorophenylamino)-1-(4-nitrophenyl)-3-oxoprop-1-en-2-yl)-2-methoxybenzamide for preventing and treating neurodegenerative diseases is provided to suppress A beta decomposition and to prevent and treat Alzheimer' disease. CONSTITUTION: A pharmaceutical composition for preventing and treating Alzheimer's disease, Parkinson' disease, amylotrophic lateral scelerosis(ALS), or dementia contains (Z)-N-(3-(2,4-difluorophenylamino)-1-(4-nitrophenyl)-3-oxoprop-1-en-2-yl)-2-methoxybenzamide or a pharmaceutically acceptable salt thereof as an active ingredient. The compound of chemical formula 1 specifically suppresses a SI pocket of GCP II(Glutamate Carboxypeptidase II) and strengthens synapse at an early stage. The compound of chemical formula 1 maintains homeostasis of intracellular amyloid beta(A beta).본 발명은 (Z)-N-(3-(2,4-디플루오로페닐아미노)-1-(4-나이트로페닐)-3-옥소프로프-1-엔-2-일)-2-메톡시벤즈아마이드((Z)-N-(3-(2,4-difluorophenylamino)-1-(4-nitrophenyl)-3-oxoprop-1-en-2-yl)-2-methoxybenzamide) 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 신경퇴행성 질환 예방 및 치료용 약학적 조성물에 관한 것으로, 구체적으로 본 발명에 따른 화합물은 GCPⅡ의 S1 포켓을 특이적으로 억제하여 Aβ의 분해를 억제함으로써, 시냅스 강화가 일어나며, 질환의 진행 단계에 따라 Aβ의 항상성 유지에 중요한 역할을 할 수 있어 알츠하이머 질환의 예방 및 치료용 약학적 조성물로 유용하게 이용될 수 있다.
