The present invention relates to an in vitro method for obtaining a biohybrid vector comprising the step of contacting at least one extracellular vesicle (EV) with at least one liposome containing a compound of interest, wherein a fusion between the extracellular vesicle and the liposome is performed in the presence of polyethylene glycol (PEG). The present invention also relates to a biohybrid vector obtained from the method of the invention and its medical application.
