Meiser Felix,Norret Marck,Bosch H William,Russell Adrian,Dodd Aaron
申请号：
NZ71038410
公开号：
NZ710384A
申请日:
2010.04.23
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed are methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments. wherein when tested using USP Apparatus I (baskets) set to rotation speed of 100 RPM in 900 mL of 100mM citric acid buffer at pH 5.5±0.05 at 37±0.5°C, the milled indomethacin has a dissolution profile of no less than 50% dissolution, by weight, at 60 minutes, when measured under sink conditions.
