THE PRESENT INVENTION PROVIDES A TOPICAL FORMULATION INCLUDING (I) COMFREY OR A COMFREY- DERIVED COMPOUND, OR AN ANALOGUE OR DERIVATIVE THEREOF AND (II) A PENETRATION ENHANCER, AND OPTIONALLY INCLUDING TANNIC ACID, OR AN ANALOGUE OR DERIVATIVE THEREOF. THE PRESENT INVENTION ALSO PROVIDES A TOPICAL FORMULATION INCLUDING (I) COMFREY OR A COMFREY-DERIVED COMPOUND, OR AN ANALOGUE OR DERIVATIVE THEREOF, AND (II) TANNIC ACID, OR AN ANALOGUE OR DERIVATIVE THEREOF, OPTIONALLY INCLUDING A PENETRATION ENHANCER. ALSO PROVIDED ARE KITS AND METHODS OF PROPHYLACTIC OR THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR DEGENERATIVE CONDITIONS USING THE COMBINATION OF ACTIVE INGREDIENTS AS HEREIN DESCRIBED.