Cheung Jeanne,Lehar Sophie M,Mariathasan Sanjeev,Irving Bryan,Wu Yan,Maecker Heather,Chiu Henry
申请号：
NZ71721309
公开号：
NZ717213A
申请日:
2009.12.08
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Discloses isolated host cells comprising anti programmed death ligand 1 (PD-L1) antibodies or nucleotides encoding anti-PD-L1 antibodies. The anti PD-L1 antibody heavy chain comprises an HVR-H1, HVR-H2 and HVR-H3 with the sequences of GFTFSDSWIH (SEQ ID NO:15), AWISPYGGSTYYADSVKG (SEQ ID NO:16) and RHWPGGFDY (SEQ ID NO:3), respectively. The light chain comprises LVR-L1, LVR-L2 and LVR-L3 with the sequences of RASQDVSTAVA (SEQ ID NO:17), SASFLYS (SEQ ID NO:18) and QQYLYHPAT (SEQ ID NO:19), respectively. Further discloses wherein the heavy chain comprises the sequence: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGG STYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA (SEQ ID NO:20), and the light chain comprises the sequence: DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYH PATFGQGTKVEIKR (SEQ ID NO:21).
