Austin L. Gurney,Fumiko Takada Axelrod,Timothy Charles Hoey,Cecile Chartier-Courtaud
申请号：
US14795811
公开号：
US09644034B2
申请日:
2015.07.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
