PROCEDE DE TRAITEMENT DE CHELOIDES OU DE CICATRICES HYPERTROPHIEES A L'AIDE DE COMPOSES ANTISENS CIBLANT UN FACTEUR DE CROISSANCE DE TISSU CONJONCTIF (CTGF)
DEAN, NICHOLAS M.,KROCHMAL, LINCOLN,HARDEE, GREGORY,FOULKES, J. GORDON,O'DONNELL, NIALL,YOUNG, LEROY,JEWELL, MARK
申请号：
CA2825059
公开号：
CA2825059A1
申请日:
2012.02.02
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
