Laura Marrone;Ahmad Ghavami;Sundaramma Viswanatha;Thammaiah Viswanatha;Valerie Joy Goodfellow;Jarrod W. Johnson;Anthony Paul Krismanich;Gary Igor Dmitrienko
发明人:
Gary Igor Dmitrienko,Ahmad Ghavami,Valerie Joy Goodfellow,Jarrod W. Johnson,Anthony Paul Krismanich,Laura Marrone,Thammaiah Viswanatha,Sundaramma Viswanatha
申请号：
US13581301
公开号：
US20120329770A1
申请日:
2011.02.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to cephalosporin derivatives having β-lactamase inhibitory activity. The compounds are useful in preventing or treating bacterial resistance to an antibiotic, e.g. a β-lactam antibiotic. Disclosed herein are compounds that are inhibitors of class B metallo-β-lactamases, as well as class A, C, and D serine β-lactamases. In some preferred embodiments, the compounds are 3′-thiobenzoate derivatives of a cephalosporin. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the compounds are also disclosed.
