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Gene products of differential expression in tumors and their use
专利权人:
Astellas Pharma Inc.
发明人:
SAHIN, Ugur,TÜRECI, Özlem,KOSLOWSKI, Michael
申请号:
ES03773719
公开号:
ES2675785T3
申请日:
2003.11.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Pharmaceutical composition for use in a method for treating a cancer disease or for vaccinating against it, comprising one or more components selected from the group consisting of: (i) an antigen associated with a tumor encoded by a nucleic acid sequence according to SEQ ID NO: 7 or 8, or a part thereof comprising at least 6 contiguous amino acids of the tumor associated antigen, (ii) a nucleic acid encoding a tumor associated antigen or a part thereof comprising at least 6 contiguous amino acids of the tumor associated antigen, wherein the tumor associated antigen is encoded by the nucleic acid sequence according to SEQ ID NO: 7 or 8, (iii) an antibody that binds to a tumor associated antigen, which is encoded by the nucleic acid sequence according to SEQ ID NO: 7 or 8, (iv) a host cell that expresses an antigen associated with a tumor or a part thereof comprising at least 6 contiguous amino acids of the a a tumor associated antigen, wherein the tumor associated antigen is encoded by the nucleic acid sequence according to SEQ ID NO: 7 or 8 and (v) isolated complexes between an antigen associated with a tumor or a part thereof and a HLA molecule, wherein the tumor-associated antigen is encoded by the nucleic acid sequence according to SEQ ID NO: 7 or 8, wherein the cancer disease is distinguished by the expression of a tumor-associated antigen that has a sequence encoded by a nucleic acid comprising a nucleic acid sequence selected from the group formed by SEQ ID NO: 7 and 8, wherein the cancer disease is a pancreas tumor, an esophageal tumor or a liver carcinoma.Composición farmacéutica para su uso en un método para tratar una enfermedad de cáncer o para vacunar contra la misma, que comprende uno o varios componentes seleccionados del grupo formado por: (i) un antígeno asociado a un tumor codificado por una secuencia de ácido nucleico según SEQ ID NO: 7 u 8, o una parte del mismo que comprende al menos 6 aminoácidos contiguos del antígeno asociado al tumor, (ii) un
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