Al-Hajj, Muhammad,Clarke, Michael F,Wicha, Max S,Morrison, Sean J
申请号：
AU2008200133
公开号：
AU2008200133B2
申请日:
2008.01.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2008200133B220120614.pdf#####POPER HPM Regentsof thc Universy ofMchigan W6H2(hdiv pagSdoc I/2(X8 ABSTRACT A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the 5 majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presende of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay 10 have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.
