Compositions and methods of use of anti-Trop-2 antibodies or antigen-binding fragments thereof for isolating, enriching, detecting, diagnosing and / or characterizing circulating tumor cells (CTC) of a Trop-2 positive cancer patient are described herein. be written. Preferably, the antibody is RS7, 162-46.2 or MAB650 antibody. Said compositions and methods comprise metastatic TROP-2 + cancers such as breast cancer, ovarian cancer, cervical cancer, endometrial cancer, lung cancer, prostate cancer, colon cancer, rectal cancer, gastric cancer, esophageal cancer, bladder cancer, It is useful for the detection, diagnosis and / or treatment of kidney cancer, pancreatic cancer, thyroid cancer, epithelial cancer or head and neck cancer. [Selection] Figure 1Ｔｒｏｐ－２陽性癌患者の循環腫瘍細胞（ＣＴＣ）を単離、濃縮、検出、診断及び／または特徴付けるための、抗Ｔｒｏｐ－２抗体またはその抗原結合断片の組成物及び使用方法が本明細書に記載される。好ましくは、当該抗体は、ＲＳ７，１６２－４６．２またはＭＡＢ６５０抗体である。前記組成物及び方法は、転移性のＴＲＯＰ－２＋癌、例えば乳癌、卵巣癌、子宮頸癌、子宮内膜癌、肺癌、前立腺癌、結腸癌、直腸癌、胃癌、食道癌、膀胱癌、腎臓癌、膵臓癌、甲状腺癌、上皮癌または頭頸部癌の検出、診断及び／または治療に有用である。【選択図】図１
