A powered surgical stapling device (10) includes an end effector (20) having a stationary anvil (30) and a cartridge assembly (32) that is supported for pivotal movement in relation to the anvil (30). In embodiments, the end effector (20) includes a housing (22) that supports an input shaft (24), an anvil (30) fixedly supported on the housing (22), and a cartridge assembly (32) pivotally supported in relation to the housing (22) and the anvil (30). The cartridge assembly (32) includes a channel (46) that is pivotally supported on the housing (22). A lead screw (54) is positioned within the channel (46) and supports an internally threaded dynamic clamping member (42). The lead screw (54) is secured to the input shaft (24) by a universal joint (80) such that rotation of the input shaft (24) effects rotation of the lead screw (54) and longitudinal translation of the dynamic clamping member (42) along the lead screw (54). The universal joint (80) facilitates the translation of the rotatable movement of the input shaft (24) into rotation of the lead screw (54) while allowing pivotal movement of the lead screw (54) in relation to the input shaft (24).