CHOSUN UNIVERSITY;조선대학교산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY
发明人:
PARK, YOON KYUNG,박윤경
申请号：
KR1020120000952
公开号：
KR1020130080172A
申请日:
2012.01.04
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A novel antifungal peptide isolated from Solanum tuberosum L cv. Jopung is provided to have an antifungal activity against Candida albicans and to be used in pharmaceutical compositions, cosmetic compositions, agrochemicals, preservatives for foods, cosmetics, and pharmaceutical products. CONSTITUTION: An antifungal peptide has an amino acid sequence of sequence number 1 and is isolated from Solanum tuberosum L cv. Jopung. The molecular weight of the antifungal peptide is 1.0831 kDa. A method for preparing the peptide comprises the steps of: freeze-drying and pulverizing bulbs of Solanum tuberosum L cv. Jopung； extracting the pulverized bulbs and preparing an extract； centrifuging the extract and collecting a supernatant fraction； and isolating and purifying the supernatant fraction by chromatography. An antifungal pharmaceutical composition contains the peptide as an active ingredient.본 발명은 감자(Solanumtuberosum L cv. Jopung)로부터 분리한 펩타이드에 관한 것으로, 보다 상세하게는 본 발명의 감자(Solanumtuberosum L cv. Jopung)로부터 분리한 서열번호 1로 기재되는 아미노산 서열로 구성되는 항진균 펩타이드인 포타이드-제이(Potide-J)는 캔디다 알비칸스(Candida albicans)에 대하여 항진균 활성이 뛰어나며, 세포 독성을 나타내지 않으므로 본 발명의 펩타이드를 유효성분으로 함유하는 약학적 조성물, 화장료 조성물, 농약, 식품방부제, 화장품 보존제 및 의약품 보존제로 유용하게 사용될 수 있다.
