The present invention relates to a mixing tip coupling structure for impression-material cartridges, and more specifically relates to a structure for the coupling of an impression-material cartridge which is formed with an upper coupling plate in the middle of the upper parts of a pair of cylinders and is provided with mutually facing mixing-tip-coupling end parts on either side of the upper coupling plate, and a mixing tip which is formed with a projecting mixing tube having mixing screw inserted in the middle of the upper part and is formed with projecting coupling flanges on either side of the lower end part it being a mixing-tip coupling structure for impression-material cartridges wherein the side surfaces of the very end parts of the coupling flanges, which are formed on either side of the lower end part of the mixing tip, are respectively formed with diagonally symmetrical rotationally engaging protrusions.