The present invention provides a pharmaceutical composition for inhibiting inflammatory reaction or promoting skin keratin metabolism, comprising an effective dose of 7,16-Dioxo-7,16-dideoxylimondiol, 2R,3R,4S,5R-2-(6-amino-9H- purin-9-yl)-5-(hydroxymethyl)oxolane-3,4- diol, p-Hydroxybenzoic acid, (2E)-3- Phenylprop-2-enoic acid, or a mixture thereof. The pharmaceutical composition can effectively inhibit keratinocyte secretion of inflammatory factors and promote keratinocyte proliferation.本發明提供一種含有效劑量之7,16-二氧-7,16-二脫氧檸檬二醇、2R,3R,4S,5R-2-(6-氨基-9H-嘌呤-9-基)-5-(羥甲基)氧雜環戊烷-3,4-二醇、對羥基苯甲酸、(2E)-3-苯基丙-2-烯酸、或其混合物之醫藥組合物用於抑制發炎反應及促進皮膚角質代謝的用途，能有效抑制角質細胞分泌發炎因子、及促進角質細胞增生。
