Raffaella Faggioni;Scott Klakamp;Mary Haak-Frendscho;Jaspal S. Kang;Palaniswami Rathanaswami;John S. Babcook;Larry Green;Gio;Kathy Manchulenko;Meina Liang;Yen-Wah Lee;Orit Foord;Xiao Feng;Craig Pigott
发明人:
John S. Babcook,Jaspal S. Kang,Orit Foord,Larry Green,Xiao Feng,Scott Klakamp,Mary Haak-Frendscho,Palaniswami Rathanaswami,Craig Pigott,Meina Liang,Yen-Wah Lee,Kathy Manchulenko,Raffaella Faggioni,Gio
申请号：
US11876669
公开号：
US08101178B2
申请日:
2007.10.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
