PROBLEM TO BE SOLVED: To provide an antiarrhythmic and an atrial fibrillation inhibitor having excellent inhibitory action to a cardiac arrhythmias including an atrial fibrillation, having fewer side-effects, and being highly safe, a model of sustained atrial fibrillation, as well as a production method thereof, suitable to use for screening of the atrial fibrillation inhibitor, and a screening method of the atrial fibrillation inhibitor capable of screening the atrial fibrillation inhibitor efficiently and conveniently by using the model of sustained atrial fibrillation.SOLUTION: The production method of the model of sustained atrial fibrillation includes: an atrium hypertrophy expansion process for inserting an electrode catheter in an atrioventricular node region of a dog, energizing a high frequency from the electrode catheter to the atrioventricular node region to destroy the atrioventricular node, and blocking the atrioventricular conduction to hypertrophy and expand an atrium and an atrial pacing process for pacing the hypertrophied and expanded atrium.COPYRIGHT: (C)2013,JPO&INPIT【課題】心房細動を含む不整脈に対して優れた抑制作用を有し、副作用が少なく安全性の高い抗不整脈剤、心房細動抑制剤、該心房細動抑制剤のスクリーニングに好適に利用できる持続性心房細動モデル及びその製造方法、並びに、前記持続性心房細動モデルを用いて心房細動抑制剤を効率よく簡便にスクリーニングできる心房細動抑制剤のスクリーニング方法の提供。【解決手段】イヌの房室結節領域に電極カテーテルを挿入し、前記電極カテーテルから前記房室結節領域に高周波を通電して前記房室結節を破壊し、房室伝導をブロックさせて心房を肥大拡大させる心房肥大拡大化工程と、肥大拡大化した前記心房をペーシングする心房ペーシング工程と、を含む持続性心房細動モデルの製造方法である。【選択図】図5C
