A pill dispenser system the device is lockable and able to hold and dispense premanufactured roll(s) of medication with pouches linked together in a continuous strip. The premanufactured roll of medication pouches is manufactured according to a prescribed dosage schedule. The pill dispenser system includes a combination of dispenser assembly including a housing having a first-member, and a second-member, computer components, a premanufactured roll of medication, an adjustable holder, a roll advancing mechanism, a separator, a securer, a power source, a user-interface, at least one locking mechanism, at least one sensor, and a code reader providing a safe and convenient way for patients and caregivers to manage medication-dosing schedules.