< Topic >Stabilizing the emission characteristic where it possesses the fast releasing section and the controlled release section, the pH dependancy is little and at the time of early liquating with same effective characteristic and is superior, it offers the persistent solid medicine formulation which it possesses.SolutionsThis invention being the solid medicine form which possesses the fast releasing section and the controlled release section the medicinal effect component and the especially anesthetic active ingredient as the active ingredient in the formulation which it contains, contains the active ingredient to Riyoube, furthermore as an additive the part alpha conversion starch and low it is something regarding the persistent solid medicine formulation which features that the degree of substitution hydroxypropyl cellulose is contained in the said fast releasing section. This invention formulation, the kind of situation which the controlled release section component mixes into the fast releasing section more or less with the difference of making tablet method of the multilayer lock causing, the pH non dependant quick early liquation behavior which is stabilized is shown, even from the aspect of the necessity that, furthermore loss and the crack or the being lacking etc do not generate the occasion where coating it does the tablet, it is practical as the formulation which possesses sufficient hardness.【課題】速放部及び徐放部を有し、即効性でかつ初期溶出においてpH依存性の少ない優れた放出特性を安定して有する持続性の固形医薬製剤を提供する。【解決手段】本発明は、薬効成分、特に鎮痛活性成分を有効成分として含有する製剤において、速放部及び徐放部を有する固形医薬形状であって、両部に有効成分を含有し、さらに該速放部には添加剤として部分アルファー化デンプン及び低置換度ヒドロキシプロピルセルロースを含有することを特徴とする持続性固形医薬製剤に関するものである。本発明製剤は、多層錠の打錠方法の違いによって徐放部成分が速放部に多少混入するような事態が生じても、安定したpH非依存性の迅速な初期溶出挙動を示し、さらに錠剤をコーティングする際に摩損や割れ及び欠け等が発生しないという必要性の面からも、充分な硬度を有する製剤として実用的である。
