To provide a medical treatment device wherein the antithrombotic property andlubricity of a coating formed on the surface can be maintained in a stablestate for a long period and also to provide a method for manufacturing thesame. A mixture solution for coating wherein a copolymer of methyl vinyl etherwith maleic acid anhydride, a quaternary ammonium salt and a polyether blockamide dissolved in an organic solvent are applied upon the surface of asubstrate comprising synthetic resin to form a coating and then urokinase andheparin are impregnated in the coating of the medical treatment device. Thesynthetic resin comprising the substrate is polyurethane, polyvinyl chloride,nylon or nylon elastomer. The quaternary ammonium salt istridodecylmethylammonium chloride. An alkaline treatment is applied to apredetermined part of a substrate upon which a coating has been formed byapplication of the mixture solution.
